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OCR: glucose-lowering insulin is normally the only y significant hormone to circulate in biol are cases where amounts; however, in some form insulin patients have an inborn inab nts with islet rtially split from proinsulin, and in som cell tumours, proinsulin and ing products are the dominant ci sulin and hypoglycaemic hormones. B output and proinsulin reduce hepatic glu dependent increase glucose uptake by in ilin receptors. tissues after binding to specif